It is a paranoid thriller about a family on the run from a natural crisis that presents a large-scale threat to humanity. A pandemic of unknown cause is spreading across the northeast of the US, mysteriously within well-defined borders. Victims experience loss of speech and physical disorientation; they freeze, and then unfreeze to commit suicide: people jump from buildings, shoot or hang themselves, one feeds himself to lions in the zoo, some cut themselves with a hairpin, barbed wire, glass, or a grass mower, drive into a tree, etc. The initial assumption that it is a terrorist attack is abandoned.
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